CAM Drug – Herb Interaction Chart References

Dong Quai

Page RL, Lawrence JD
Potentiation of Warfarin by dong quai.
Pharmacotherapy
1999;19:870-6

Echinacea

See DM, Broumand N, Sahl L, Tilles JG
In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients.
Immunopharmacology
1997;35:229-235

Ephedra/Ma Huang

Haller CA, Benowitz NL
Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids.
N Engl J Med
2000;343:1833-1838

Powell T, Hsu FF, Turk J, Hruska K
Ma-huang strikes again: ephedrine nephrolithiasis.
Am J Kidney Dis
1998;32:153-159

White LM, Gardner SF, Gurley BJ, Marx MA, Wang PL, Estes M
Pharmacokinetics and cardiovascular effects of ma-huang (Ephedra sinica) in normotensive adults.
J Clin Pharmacol
1997 Feb;37(2):116-22

Garlic

Srivastava KC
Evidence for the mechanism by which garlic inhibits platelet aggregation.
Prostaglandins Leukot Med
1986 Jun;22(3):313-21

Apitz-Castro R, Escalante J, Vargas R, Jain MK
Ajoene, the antiplatelet principle of garlic, synergistically potentiates the antiaggregatory action of prostacyclin, forskolin, indomethacin and dypiridamole on human platelets.
Thromb Res
1986;42:303-311

Silagy CA, Neil HA
A meta-analysis of the effect of garlic on blood pressure.
J Hypertens
1994 Apr;12(4):463-8

Ginger

Phillips S, Ruggier R, Hutchinson SE
Zingiber officinale (ginger)--an antiemetic for day case surgery.
Anaesthesia
1993 Dec;48(12):1118

Gingko Biloba

Le Bars PL, Katz MM, Berman N, Itil TM, Freedman AM, Schatzberg AF
A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia: North American EGb Study Group.
JAMA
1997;278:1327-1332

Oken BS, Storzbach DM, Kaye JA
The efficacy of Ginkgo biloba on cognitive function in Alzheimer disease.
Arch Neurol
1998;55:1409-1415

Ginseng

Janetzky K, Morreale AP
Probable interaction between warfarin and ginseng.
Am J Health Syst Pharm
1997;54:692-693

Goldenseal

Rehman J, Dillow JM, Carter SM, Chou J, Le B, Maisel AS
Increased production of antigen-specific immunoglobulins G and M following in vivo treatment with the medicinal plants Echinacea angustifolia and Hydrastis canadensis.
Immunol Lett
1999 Jun 1;68(2-3):391-5

Kava Kava

Pittler MH, Ernst E
Efficacy of kava extract for treating anxiety: systematic review and meta-analysis.
J Clin Psychopharmacol
2000 Feb;20(1):84-9

Jappe U, Franke I, Reinhold D, Gollnick HPM
Sebotropic drug reaction resulting from kava kava extract therapy: A new entitity?
J Amer Acad Dermatol
1998;38:104–6

Licorice

Fujisawa Y, Sakamoto M, Matsushita M, Fujita T, Nishioka K
Glycyrrhizin inhibits the lytic pathway of complement--possible mechanism of its anti-inflammatory effect on liver cells in viral hepatitis
Microbiol Immunol
2000;44(9):799-804

SAM-e

Fava M, Giannelli A, Rapisarda V, Patralia A, Guaraldi GP
Rapidity of onset of the antidepressant effect of parenteral S-adenosyl-L-methionine
Psychiatry Res
1995 Apr 28;56(3):295-7

St. John’s Wort

Gaster B, Holroyd J
St John's wort for depression: a systematic review.
Arch Intern Med
2000;160:152-156

Shelton RC, Keller MB, Gelenberg A, et al
Effectiveness of St John's wort in major depression.
JAMA
2001;285:1978-1986

Lantz MS, Buchalter E, Giambanco V
St. John's wort and antidepressant drug interactions in the elderly.
J Geriatr Psychiatry Neurol
1999;12:7-10

Valerian

Donath F, Quispe S, Diefenbach K, Maurer A, Fietze I, Roots I
Critical evaluation of the effect of valerian extract on sleep structure and sleep quality
Pharmacopsychiatry 2000 Mar;33(2):47-53

Other recommended journal articles regarding herbal supplements:

Ang-Lee MK, Moss J, Yuan C
Herbal Medicines and Perioperative Care
JAMA
2001;286: 208-216

Kaye AD, Clarke RC, Sabar R, et al
Herbal medications: current trends in anesthesiology practice–a hospital survey.
J Clin Anesth
2000;12:468-471

Eisenberg DM, Davis RB, Ettner SL, et al
Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up study.
JAMA
1998;280:1569-1575

Blendon RJ, DesRoches CM, Benson JM, Brodie M, Altman DE
American's views on the use and regulation of dietary supplements.
Arch Intern Med
2001;161:805-810

Miller LG
Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions.
Arch Intern Med
1998 Nov 9;158(20):2200-11

Klepser TB, Klepser ME
Unsafe and potentially safe herbal therapies.
Am J Health Syst Pharm
1999 Jan 15;56(2):125-38

Hensrud DD, Engle DD, Scheitel SM
Underreporting the use of dietary supplements and nonprescription medications among patients undergoing a periodic health examination.
Mayo Clin Proc
1999;74:443-447

Anesthesiologists warn: if you're taking herbal products, tell your doctor before surgery.

FDA's Summary of DSHEA
http://vm.cfsan.fda.gov/~dms/dietsupp.html

Full text of DSHEA at HealthWorld Online
http://www.healthy.net/public/legal-lg/fedregs/S784_ENR.HTM>